Recent advance in role of mitochondrial transfer in spinal cord injury
10.3760/cma.j.cn115354-20240103-00008
- VernacularTitle:线粒体转移在脊髓损伤治疗中的研究进展
- Author:
Sijia PENG
1
;
Yichen MENG
;
Miao HU
;
Xuhui ZHOU
Author Information
1. 上海理工大学健康科学与工程学院，上海 200093
- Keywords:
Spinal cord injury;
Mitochondria transfer;
Never regeneration
- From:
Chinese Journal of Neuromedicine
2024;23(6):613-617
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial dysfunction after spinal cord injury (SCI) is recognized as a crucial pathological mechanism for secondary SCI. Studies have indicated that mitochondrial transfer plays a significant role in the process of neural regeneration following injury. After mitochondria migrating to injured neurons, they mainly function via enhancing the energy metabolism level of damaged neurons and reducing oxidative stress. In this article, we present an exhaustive overview on mechanism of mitochondrial transfer, and impact on neural regeneration after mitochondrial transfer so as to provide valuable insights for further exploring the role of mitochondrial transfer in SCI progression and offer innovative perspective on potential therapeutic strategies for SCI.
