Morphometric analysis program in detecting focus of pediatric epilepsy related to focal cortical dysplasia II
10.3760/cma.j.cn115354-20240513-00293
- VernacularTitle:形态学分析测定程序在儿童局灶性皮质发育不良Ⅱ型病灶影像检出中的应用价值研究
- Author:
Yazhou XING
1
;
Ting ZHAO
;
Shenglong LAI
;
Hongye FAN
Author Information
1. 河南省人民医院神经外科，郑州 450003
- Keywords:
Epilepsy;
Focal cortical dysplasia;
Morphometric analysis program;
Children
- From:
Chinese Journal of Neuromedicine
2024;23(6):603-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of morphometric analysis program (MAP) in detecting focus of pediatric epilepsy related to focal cortical dysplasia (FCD) II.Methods:A retrospective analysis was performed; 42 epilepsy children with FCD II and postoperative Engel grading I in Department of Neurosurgery, He'nan Provincial People's Hospital from June 2020 to January 2023 were enrolled. Preoperative MRI data were analyzed by MAP. Difference in general data and focus detection rate by MRI and MAP were compared between the positive MAP group and negative MAP group, and consistency of MAP positive areas (true positive MAP and false positive MAP by postoperative CT) with interictal PET low metabolism positive areas was analyzed.Results:Of the 42 children, 28 had positive MAP and 14 had negative MAP in the epileptogenic focus. Gender was statistically different between positive MAP group and negative MAP group ( P<0.05). MAP had significantly better performance in focus detection compared with MRI (28/42 vs. 19/42, P<0.05). Significant difference was noted between consistency of true positive MAP area with interictal PET low metabolism positive areas (40/43) and that of false positive MAP area with interictal PET low metabolism positive areas (4/33, P<0.05). Conclusion:MAP can improve the focus detection rate of pediatric epilepsy related to FCD II effectively, and PET contributes to rule out false positive results.
