Application and progress of optogenetic technique in neural circuits in depression
10.3760/cma.j.cn115354-20240503-00272
- VernacularTitle:光遗传学技术在抑郁症神经环路研究中的应用与进展
- Author:
Shaowei LI
1
;
Sheng WEI
;
Jiehui LI
;
Siyuan LIU
;
Yalin CAO
;
Haijun WANG
Author Information
1. 山东中医药大学中医学院，国家中医药管理局高水平中医药重点学科中医基础理论学科，济南 250355
- Keywords:
Optogenetic technique;
Neural circuit;
Depression;
Neuroregulation
- From:
Chinese Journal of Neuromedicine
2024;23(5):520-525
- CountryChina
- Language:Chinese
-
Abstract:
Optogenetic technique is a cellular activity regulation technology that combines optics and genetics, which can specifically regulate the relevant brain regions and neural circuits in depressive animal models, thereby slowing down or aggravating depression-like behaviors in experimental animals. Optogenetic technique combined with neuroimmunoassay, behavioral detection and brain imaging techniques can provide technical support for elucidating the pathogenesis of depression, developing new antidepressants and diagnosis and treatment methods. In this paper, the application of optogenetic technique in the ventral tegmental area, nucleus accumbens, prefrontal cortex, hippocampus, dorsal raphe nucleus and other brain regions closely related to depression is reviewed to provide ideas and directions for study of neural circuits of depression.
