Recent advance in immune microenvironment of cerebral atherosclerosis
10.3760/cma.j.cn115354-20231225-00321
- VernacularTitle:脑动脉粥样硬化免疫微环境研究进展
- Author:
Chenming SI
1
;
Yanyan HE
;
Yingkun HE
;
Jia LIANG
;
Taoyuan LU
;
Chenqing LI
;
Tianxiao LI
Author Information
1. 郑州大学人民医院（河南省人民医院）脑血管病科，郑州 450003
- Keywords:
Cerebral atherosclerosis;
Immune microenvironment;
Immune cell;
Cytokine
- From:
Chinese Journal of Neuromedicine
2024;23(5):500-506
- CountryChina
- Language:Chinese
-
Abstract:
A large number of non-specific immune cells, such as macrophages, neutrophils and natural killer cells, as well as specific immune cells, such as B cells and T cells, are presented in the atherosclerotic plaques and arterial blood. In addition, immune-related regulatory molecules such as interferon-γ, interleukin-17, and interleukin-1β highly express in atherosclerotic lesion tissues, which is similar to the tumor immune microenvironment and influence the atherosclerosis progression. In this paper, the research progress of immune cells and related factors involved in the immune microenvironment around cerebral atherosclerotic lesions is reviewed to provide idea and basis for its clinical diagnosis and treatment.
