Recent advance in immune inflammatory response mechanism in Japanese encephalitis
10.3760/cma.j.cn115354-20240313-00160
- VernacularTitle:流行性乙型脑炎免疫炎症反应机制的研究进展
- Author:
Yuanyuan LIU
1
;
Yanzong ZHAO
;
Jing YANG
;
Yuqing TAN
;
Shangyun ZHANG
;
Jianing YE
;
Handan XIAO
;
Weitao WANG
;
Tianhong WANG
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Keywords:
Japanese encephalitis;
Japanese encephalitis virus;
Central nervous system;
Inflammation;
Immune response
- From:
Chinese Journal of Neuromedicine
2024;23(4):427-432
- CountryChina
- Language:Chinese
-
Abstract:
Japanese encephalitis is an acute central nervous system infectious disease caused by Japanese encephalitis virus (JEV) with brain parenchyma inflammation, characterized by high fever, headache, positive meningeal irritation, impaired consciousness, convulsion, and respiratory failure, with mortality rate as high as 20%-30%, and with neurological sequelae in 30%-50% of survivors. The mechanism of brain damage caused by JEV infection is still unclear, and some studies imply its close relation with immune-inflammatory response. This article reviews the research progress on immune-inflammatory response mechanism of Japanese encephalitis to help to understand its pathogenesis.
