Recent advance in 7T MRI in Alzheimer's disease
10.3760/cma.j.cn115354-20231203-00268
- VernacularTitle:7T MRI在阿尔茨海默病中的研究进展
- Author:
Zhen ZHANG
1
;
Qihao GUO
Author Information
1. 上海交通大学医学院附属第六人民医院老年病科，上海 200233
- Keywords:
Alzheimer's disease;
7T MRI;
Neurodegeneration
- From:
Chinese Journal of Neuromedicine
2024;23(4):417-420
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is the most common cause of cognitive impairment. Beyond clinical diagnosis, AD pathologic changes are considered as "gold standard" for mechanistic research or new drug development studies. According to AD research framework, neurodegeneration occurs after amyloid-β and Tau protein deposition and before cognitive decline. Due to lower-and medium-field MRI limitation, most of these neurodegenerative characteristics identified at present appear at middle or late stage of AD, hardly being an early warning signal. 7T MRI system, representing the most advanced field strength MRI presently, is characterized by its exceptional resolution and sensitivity that facilitate the early identification of neurodegeneration. This article reviews the recent advance in 7T MRI in AD spectrum and brain structures associated with AD, aiming to enhance the utilization of 7T MRI in this field.
