Recent advance in synaptic plasticity alteration in Fragile X syndrome
10.3760/cma.j.cn115354-20240102-00001
- VernacularTitle:突触可塑性改变在脆性X综合征中的研究进展
- Author:
Na QI
1
;
Xi WU
;
Min LI
;
Junyu HUANG
;
Yan ZENG
;
Liang CHEN
;
Zhen WEI
Author Information
1. 武汉科技大学医学部脑科学先进技术研究院，武汉 430065
- Keywords:
Fragile X syndrome;
Fragile X mental retardation protein;
Synaptic plasticity
- From:
Chinese Journal of Neuromedicine
2024;23(4):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Fragile X syndrome (FXS) is a neurodevelopmental synaptopathy caused by loss of fragile X mental retardation protein (FMRP); abnormal synaptic plasticity is the leading pathological cause of cognitive impairment, fear and anxiety, hyperactivity and stereotyped behavior in FXS patients. In recent years, breakthroughs have been made in functional study of synaptic plasticity in FXS, providing a new theoretical basis for FXS. This article mainly summarizes the dysregulation and influencing factors of synaptic plasticity in FXS, as well as the strategy of targeted synaptic plasticity in FXS, so as to deepen the understanding of medical workers.
