Research progress on the relationship between astrocyte glycolysis and cognitive impairment of Alzheimer′s disease

VernacularTitle:星形胶质细胞糖酵解与阿尔茨海默病认知障碍关系的研究进展
Author: Peiyu MAO ¹ ; Hui LI ; Yugang JIANG
Author Information

1. 军事医学研究院，天津300050
Keywords: Astrocytes; Glycolysis; Alzheimer disease; Cognition
From: Chinese Journal of Neurology 2024;57(11):1289-1296
CountryChina
Language:Chinese
Abstract: Alzheimer′s disease (AD) is a neurodegenerative disease with insidious onset and progressive development, with high disability and mortality rate. At present, there is no effective therapeutic drug. With the acceleration of population aging in China, AD poses a serious threat to public health system and social economy. Recent studies have found that the glycolysis disorder of astrocytes is involved in the progress of AD, which is closely related to the cognitive impairment of AD. The relationship between glycolytic metabolism of astrocytes and cognitive function was reviewed, and the relationship between glycolytic damage of astrocytes and cognitive impairment of AD and its mechanism were elaborated in detail, in order to provide reference for further understanding the new mechanism of cognitive impairment of AD and formulating clinical prevention and treatment strategies for AD.