Multimodal positron-emission tomography-computed tomography manifestations in a case with frontotemporal dementia with parkinsonism
10.3760/cma.j.cn113694-20240410-00224
- VernacularTitle:1例额颞叶痴呆并帕金森综合征患者的多模态正电子发射体层摄影-电子计算机体层扫描表现
- Author:
Jingyu SHAO
1
;
Chang FU
;
Junling XU
;
Shuai CHEN
;
Hongqi YANG
;
Jiewen ZHANG
Author Information
1. 郑州大学人民医院 河南省人民医院神经内科，郑州 450003
- Keywords:
Dementia;
Positron-emission tomography;
Tomography, X-ray computed;
Parkinsonism;
Tauopathy
- From:
Chinese Journal of Neurology
2024;57(11):1254-1258
- CountryChina
- Language:Chinese
-
Abstract:
Frontotemporal dementia (FTD) is a group of dementia diseases mainly characterized by progressive mental-behavioral abnormalities, executive dysfunction, and language impairment. A small number of FTD patients also present with movement disorders at certain disease course. Here the clinical and multimodal positron-emission tomography (PET) imaging manifestations in a patient with frontotemporal lobe dementia and parkinsonian syndrome are reported. 18F-fluorodopa PET showed reduced uptake in the head of the caudate nucleus. 18F-AV-45 PET showed negative amyloid deposition. 18F-AV-1451 PET showed tau deposition in the neocortex. The clinical and neuroimaging features support the underlying frontotemporal lobar degeneration-tau pathology.
