Research progress on the role of central cholinergic system in gait deficits and balance disturbances in Parkinson′s disease
10.3760/cma.j.cn113694-20240104-00012
- VernacularTitle:中枢胆碱能系统参与帕金森病步态和平衡障碍的研究进展
- Author:
Lin CHEN
1
;
Juan HUANG
;
Binbin HU
;
Yajing CUI
;
Xinyue ZHANG
;
Xingyan YANG
;
Wei HUANG
Author Information
1. 南昌大学第二附属医院神经内科，南昌 330006
- Keywords:
Parkinson disease;
Gait deficits;
Balance disturbances;
Cholinergic neurons
- From:
Chinese Journal of Neurology
2024;57(10):1163-1168
- CountryChina
- Language:Chinese
-
Abstract:
Gait deficits and balance disturbances are prevalent clinical features in Parkinson′s disease (PD). There is an increasing body of evidence pointing towards the degeneration of central cholinergic neurons as a crucial factor leading to these disturbances in PD. This paper presents a comprehensive review of the relevant research on the involvement of the central cholinergic system in the mechanisms underlying gait deficits and balance disturbance in PD. The aim is to provide new perspectives and insights for the treatment of gait deficits and balance disturbances in PD.
