Assessment of blood-brain barrier dysfunction in vascular cognitive impairment: advances in magnetic resonance imaging technology research
10.3760/cma.j.cn113694-20240220-00102
- VernacularTitle:磁共振技术评估血脑屏障破坏在血管性认知障碍中的应用研究进展
- Author:
Weisen WANG
1
;
Xu SUN
;
Binghan LI
;
Xiaoying BI
;
Wenjia PENG
Author Information
1. 海军军医大学第一附属医院神经内科，上海 200433
- Keywords:
Cognition disorders;
Blood-brain barrier;
Magnetic resonance imaging
- From:
Chinese Journal of Neurology
2024;57(7):795-799
- CountryChina
- Language:Chinese
-
Abstract:
Vascular cognitive impairment is a group of disorders characterized by cognitive dysfunction caused by vascular factors. Disruption of the blood-brain barrier is an early pathophysiological mechanism of vascular cognitive impairment. Dynamic contrast-enhanced magnetic resonance imaging and arterial spin labeling-based blood-brain barrier imaging techniques can quantitatively assess the integrity of the blood-brain barrier. In recent years, these techniques have gradually been applied to detect the extent of blood-brain barrier dysfunction. This article provides a comprehensive review of the basic principles of relevant magnetic resonance techniques and the progress made in their application to the assessment of the blood-brain barrier in vascular cognitive impairment.
