Recent progress of organoids and organ-on-a-chip technology in Alzheimer′s disease
10.3760/cma.j.cn113694-20240104-00008
- VernacularTitle:类器官与器官芯片技术在阿尔茨海默病中的研究进展
- Author:
Menghan ZHOU
1
;
Peiyuan ZHU
;
Leqi CAO
;
Wenying SHI
;
Fangyuan QIAN
Author Information
1. 东南大学附属中大医院神经内科，东南大学医学院，南京210009
- Keywords:
Alzheimer disease;
Organoids;
Models;
Pathogenesis;
Drug evaluation;
Organ-on-a-chip
- From:
Chinese Journal of Neurology
2024;57(7):789-794
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease (AD) is a neurodegenerative disorder. In the past few decades, the exact mechanisms underlying the onset of the disease have remained unclear, and treatment options are still lacking. Due to the inability of two-dimensional cell and animal models to fully simulate the pathogenesis of AD, there have been shortcomings in clinical trials of new drugs. The development of organoids and organ-on-a-chip technologies has improved the dilemma of AD research, providing reliable in vitro research models for studying pathogenic mechanisms and drug screening. This article elaborates on the applications and progress of organoids and organ-on-a-chip in AD modeling, pathogenesis, and drug development, and discusses the current limitations of organoids and organ-on-a-chip and their future perspectives.
