Clinical and imaging analysis of COVID-19-related osmotic demyelination syndrome
10.3760/cma.j.cn113694-20231101-00286
- VernacularTitle:新型冠状病毒感染相关渗透性脱髓鞘综合征的临床和影像特征分析
- Author:
Yuyue QIU
1
;
Chenhui MAO
;
Jialu BAO
;
Li SHANG
;
Tianyi WANG
;
Bo LI
;
Yixuan HUANG
;
Yuhan JIANG
;
Shanshan CHU
;
Wei JIN
;
Liling DONG
;
Feng FENG
;
Jing GAO
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科，疑难重症及罕见病国家重点实验室，北京 100730
- Keywords:
Osmotic demyelination syndrome;
COVID-19;
Magnetic resonance imaging;
Clinical manifestation;
Prognosis
- From:
Chinese Journal of Neurology
2024;57(7):763-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical and imaging features of patients with COVID-19-related osmotic demyelination syndrome (ODS).Methods:COVID-19-related ODS cases diagnosed in the Department of Neurology, Peking Union Medical College Hospital from January 2020 to September 2023 were retrospectively reviewed. And their past medical history, possible triggers, clinical manifestations, imaging manifestations, treatment and prognosis were summarized.Results:A total of 5 patients with COVID-19-related ODS were included. Electrolyte disturbances acted as an inducement of ODS in all patients (5/5),4 of whom with hyponatremia. Four of 5 patients first presented with disturbance of consciousness, followed by predominant dystonia. Imaging of all patients (5/5) showed isolated extrapontine myelinolysis (EPM). With the prolongation of the course of disease, such signal intensity could return to normal, and lesions showed atrophic changes in some patients. The patients′ clinical symptoms were partly relieved within a few days to a few months after treatment.Conclusions:COVID-19-related ODS is mostly associated with hyponatremia, and EPM is more common. COVID-19 should be considered as a risk factor for ODS.
