Effect of dynamic changes of microglia on oligodendrocytes in animal model of multiple sclerosis
10.3760/cma.j.cn113694-20240319-00167
- VernacularTitle:多发性硬化动物模型中小胶质细胞动态变化对少突胶质细胞的影响
- Author:
Shuwen YUAN
1
;
Kerong QI
;
Qingqing LIU
;
Xue CHEN
;
Jianchao SI
;
Shengchang YANG
Author Information
1. 山西中医药大学基础医学院，晋中 030619
- Keywords:
Multiple sclerosis;
Microglia;
Oligodendrocyte;
Remyelination;
Animal model
- From:
Chinese Journal of Neurology
2024;57(6):669-677
- CountryChina
- Language:Chinese
-
Abstract:
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous syestem (CNS) triggered by an autoimmune mechanism, which is the main cause of neurological disability in young people. In MS, a variety of glial cells participate in the pathogenesis and development of the disease, and oligodendrocytes (OL) and myelin cytes are destroyed by autoimmune mediated inflammation. Impaired OL production of oligodendrocyte progenitor cells (OPC) leads to persistent demyelination, myelin fragment accumulation and axonal injury, with clinical manifestation of CNS disability. Microglia (MG), which is involved in the inflammatory response and removal of myelin debris, plays a pivotal role in OPC differentiation and OL maturation, thereby directly or indirectly influencing the process of myelin regeneration. An interactive mechanism exists between these 2 components. The comprehension of the interrelationship between the 2 factors can provide enhanced insights into the pathogenesis of MS and facilitate the development of novel therapeutic strategies, thereby addressing pivotal scientific challenges encountered in clinical management of MS. Therefore, this review summarizes the dynamic changes of microglia in MS and its classic animal models, explores the internal relationship between MG and OL in this process, and focuses on the beneficial effects of targeted regulation of microglia, thereby promoting OPC differentiation and myelin regeneration, in order to provide a new research direction for MS treatment.
