Research progress of the interaction between heavy metals and ɑ-synuclein in Parkinson′s disease
10.3760/cma.j.cn113694-20230926-00196
- VernacularTitle:重金属与α-突触核蛋白相互作用在帕金森病中的研究进展
- Author:
Jinxin LIU
1
;
Yaxin KANG
;
Yuyang ZHANG
;
Xin CHEN
;
Zuxiong PAN
;
Zhengping HUANG
;
Chunnuan CHEN
Author Information
1. 福建医科大学第二临床医学院，泉州 362000
- Keywords:
Parkinson disease;
Heavy metal;
ɑ-Synuclein;
Pathogenesis;
Therapy
- From:
Chinese Journal of Neurology
2024;57(6):655-660
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease (PD) is a neurodegenerative disorder, and the abnormal levels of its pathological marker ɑ-synuclein (ɑ-syn) are often accompanied by imbalanced heavy metal homeostasis. However, the underlying mechanisms remain unclear, with limited research. This review explores the interactions between iron, copper, zinc, and manganese with pathological ɑ-syn′s abnormal expression, aggregation, and degradation in development and progression of PD. It also discusses potential therapeutic directions for addressing heavy metal imbalances in PD patients.
