Effects of ApoE4 on Alzheimer′s disease and related dementia
10.3760/cma.j.cn113694-20230913-00156
- VernacularTitle:载脂蛋白E4对阿尔茨海默病及相关痴呆的影响
- Author:
Li SHANG
1
;
Liling DONG
;
Tianyi WANG
;
Xinying HUANG
;
Chenhui MAO
;
Jing GAO
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科，北京100730
- Keywords:
Apolipoprotein E;
Alzheimer disease;
Synucleinopathy;
Frontotemporal dementia;
Dementia, vascular
- From:
Chinese Journal of Neurology
2024;57(6):649-654
- CountryChina
- Language:Chinese
-
Abstract:
The ApoE gene is a genetic risk determinant for sporadic Alzheimer′s disease (AD). The ApoEε4 allele increases the risk of developing AD relative to the common ApoEε3 allele, whereas the ApoEε2 allele decreases the risk of developing the disease. The 3 alleles encode ApoE2, ApoE3, and ApoE4 protein isoforms, respectively. ApoE4 contributes to the pathogenesis of AD by regulating β-amyloid protein, tau protein, transactive response DNA-binding protein-43, neuroinflammation, and cerebral vascular function. The pathways associated with ApoE also offer new opportunities for the treatment of AD. In addition, studies have shown that ApoE4 also plays a toxic role in other neurological disorders. This article described the biological characteristics of ApoE, as well as the impact of ApoE4 on AD and related dementias, aiming to enhance clinical doctors′ understanding of the involvement of ApoE4 in the pathogenesis of AD and related dementia.
