A case of anti-metabotropic glutamate receptor 5 encephalitis associated with Hodgkin′s lymphoma
10.3760/cma.j.cn113694-20230929-00205
- VernacularTitle:霍奇金淋巴瘤相关抗代谢型谷氨酸受体5脑炎1例
- Author:
Lin CHANG
1
;
Siyuan FAN
;
Haitao REN
;
Jia LI
;
Hongzhi GUAN
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科，北京 100730常琳现在北京航天总医院老年医学科，北京 100076
- Keywords:
Paraneoplastic syndromes, nervous system;
Hodgkin disease;
Anti-mGluR5 antibody;
Programmed cell death 1 receptor
- From:
Chinese Journal of Neurology
2024;57(6):639-641
- CountryChina
- Language:Chinese
-
Abstract:
Metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare type of anti-cell surface antigen antibody encephalitis mediated by autoimmune mechanisms. This article reported a case of anti-mGluR5 encephalitis. The patient was a 25-year-old young man with a history of Hodgkin′s lymphoma. Due to tumor recurrence, he developed encephalitis symptoms including fever, headache, mental and behavioral abnormalities, memory loss, consciousness disturbance, and seizures after checkpoint immunosuppressive therapy. He was finally diagnosed as anti-mGluR5 encephalitis by positive serum anti-mGluR5 antibodies. Finally, the symptoms alleviated after treatment with hormones and gamma globulin.
