Overview of research progress on autoimmune etiology of epilepsy

VernacularTitle:癫痫的自身免疫性病因研究进展概述
Author: Yuwei DAI ¹ ; Qing YIN ; Li YANG
Author Information

1. 中南大学湘雅二医院神经内科，长沙410011
Keywords: Autoimmune diseases of the nervous system; Epilepsy; Acute symptomatic seizures secondary to autoimmune encephalitis; Autoimmune encephalitis-associated
From: Chinese Journal of Neurology 2024;57(5):511-518
CountryChina
Language:Chinese
Abstract: In response to the controversial use of the concept of "autoimmune epilepsy", the International League Against Epilepsy has proposed conceptual definitions for 2 main diagnostic entities: acute symptomatic seizures secondary to autoimmune encephalitis (ASSAE) and autoimmune encephalitis-associated epilepsy (AEAE), which differ greatly in terms of major pathogenic antibodies, pathological changes, treatment options, and prognosis. In this review, a comprehensive interpretation of these 2 new concepts in terms of definition, epidemiology, aetiology, clinical manifestations, diagnosis and treatment is fully discussed, with the aim of addressing clinical issues in the treatment of ASSAE and AEAE, deepening neurologists′ understanding of autoimmune etiology of epilepsy.