From dark matter to fertile ground: the application and prospects of non-coding genomic regions in the diagnosis and treatment of neurogenetic disorders
10.3760/cma.j.cn113694-20240115-00032
- VernacularTitle:从暗物质到沃土：基因组非编码区在神经系统遗传病诊断与治疗中的应用及前景
- Author:
Shirui GAN
1
;
Kang YANG
;
Wanjin CHEN
;
Ning WANG
Author Information
1. 福建医科大学附属第一医院神经内科 福建医科大学附属第一医院神经病学研究所，福州 350005
- Keywords:
Non-coding region;
Neurological genetic disorders;
Genetic diagnosis;
Intervention treatment
- From:
Chinese Journal of Neurology
2024;57(5):413-418
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the field of genetics has witnessed a burgeoning interest in the non-coding region, an area previously dubbed the"dark matter"of the genome. This once enigmatic domain is now progressively revealing its secrets, emerging as a rich terrain for genetic diagnosis and treatment. This editorial centers on diverse diagnostic analyses and intervention techniques associated with the non-coding region, delving into its significance in the etiology, diagnosis, and treatment of both monogenic and polygenic disorders within the nervous system. In doing so, it offers a comprehensive perspective for the exploration of genetic disorders in the nervous system.
