Association between variability of triglyceride glucose index and risk of type 2 diabetes
10.3760/cma.j.cn114798-20240220-00096
- VernacularTitle:甘油三酯葡萄糖指数长期变异性与2型糖尿病发病风险的相关性
- Author:
Ying PAN
1
;
Shuting LIU
;
Xiaohua CHEN
;
Min HUANG
;
Yueqing HUANG
;
Yun TANG
;
Qianqian WANG
;
Kaixin ZHOU
;
Jian SHAO
;
Shao ZHONG
Author Information
1. 江苏大学附属昆山医院全科医学科，苏州 215300
- Keywords:
Diabetes mellitus, type 2;
Insulin resistance;
Triglyceride-glucose index;
Long-term variability
- From:
Chinese Journal of General Practitioners
2024;23(11):1162-1167
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between the variability of triglyceride glucose index (TyG) and the risk of type 2 diabetes mellitus(T2DM).Methods:This study was a retrospective cohort study. A total of 22 929 community-dwelling elderly (aged≥60 years) who received annual health check-ups in Kunshan city of Suzhou Municipality during 2014 to 2021 were enrolled in the study. Fasting triglycerides and blood glucose were measured during annual physical check-ups and the TyG was calculated, the standard deviation of TyG measurements in three consecutive physical check-ups was used as the indicatior of TyG long-term variability. According to the quartile of TyG long-term variability, the study subjects were divided into four groups, namely Q 1 (0-0.14), Q 2 (>0.14-0.22), Q 3 (>0.22-0.33), Q 4 (>0.33-1.90). The outcome variable was the occurrence of T2DM. The relationship between TyG variability and T2DM incidence was analyzed by multivariate Cox regression. Results:In the study cohort 11 518 (50.2%) were females and the mean age was (67.42±5.35) years. By the end of follow-up, 2 934 cases of new T2DM were diagnosed, with an oveall incidence rate of 12.8%. After adjusting for multiple confounders and average TyG, long-term variability of TyG was significantly associated with T2DM risk ( HR=1.83, 95% CI: 1.51-2.20). The risk of T2DM in Q 4 group was significantly higher than that in Q 1 group ( HR=1.33, 95% CI: 1.19-1.47). Kaplan-Meier survival curve showed that long-term variability of TyG was significantly correlated with the cumulative risk of T2DM incidence ( P<0.001). Conclusions:TyG variability is an independent risk factor for T2DM, suggesting that attention should be paid not only to specific time-point TyG levels but also to TyG fluctuation for early identification of T2DM risk.
