Predictive value of serum hs-cTnT levels for major adverse cardiovascular events in patients with chronic coronary syndrome after PCI
10.3760/cma.j.cn114798-20240805-00657
- VernacularTitle:hs-cTnT与慢性冠状动脉综合征患者PCI术后发生主要不良心血管事件的关联及其预测阈值分析
- Author:
Yaxin XU
1
;
Ru LIU
;
Qizhe WANG
;
Xiaopan LI
;
Yuxiang DAI
;
Minghui PENG
;
Sunfang JIANG
Author Information
1. 复旦大学附属中山医院健康管理中心，上海 200032
- Keywords:
Coronary artery disease;
Troponin T;
Angioplasty, balloon, coronary;
Prognosis
- From:
Chinese Journal of General Practitioners
2024;23(10):1029-1036
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of serum high-sensitivity cardiac troponin T (hs-cTnT) level with major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI) and to explore its predictive value.Methods:It was a case-control study. Clinical data of 731 patients with CCS who underwent PCI in the Affiliated Zhongshan Hospital of Fudan University between May 2019 and April 2020 were retrospectively analyzed. Baseline clinical characteristics and pre/postoperative laboratory results were gathered, and patients were followed up and the incidence of MACE was documented. The correlation of serum hs-cTnT levels with MACE was analyzed, and the threshold of hs-cTnT for predicting the occurrence of MACE was determined.Results:Among 731 patients there were 560 males (76.61%) with the age of (64.05±9.48) years. Patients were followed up for 29.9 (18.8, 35.3) months, and MACE occurred in 216 cases (MACE group), and did not occur in 515 cases (control group). The X-tile software analysis showed that the optimal cutoff value of post-PCI hs-cTnT was 4.17×upper reference limit (URL) for predicting MACE ( P=0.033). Multivariate Cox regression analysis revealed that postoperative cTnT>6×URL was an independent risk factor for MACE in CCS patients after PCI ( HR=1.87, 95% CI: 1.19-2.94, P=0.007). The net reclassification index pairwise comparison results indicated that hs-cTnT>6×URL had the better predictive performance for MACE in CCS patients after PCI compared to 7×URL, 8×URL, 9×URL, 10×URL and 15×URL (all P<0.05). Conclusion:Postoperative hs-cTnT>6×URL is an independent risk factor for MACE in CCS patients after PCI, and hs-cTnT>6×URL is the optimal threshold for predicting the risk of MACE.
