Factors related to the growth of low-risk papillary thyroid microcarcinoma based on sequential ultrasonic observation
10.3760/cma.j.cn114798-20240401-00198
- VernacularTitle:低危型甲状腺微小乳头状癌临床进程的超声观察及其增长的影响因素分析
- Author:
Guangxiang YANG
1
;
Yue LIU
;
Rong WANG
;
Yi SHEN
;
Dan LIU
Author Information
1. 大连大学附属中山医院健康管理中心，大连 116001
- Keywords:
Thyroid carcinoma;
Papillary microcarcinoma;
Clinical progress;
Ultrasound;
Growth;
Influencing factors
- From:
Chinese Journal of General Practitioners
2024;23(9):969-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the factors related to the tumor growth in subjects with low-risk papillary thyroid microcarcinoma (PTMC) based on ultrasonography.Methods:This was a cross-sectional study. A total of 136 subjects who received health check-up in Health Management Center, the Affiliated Zhongshan Hospital of Dalian University from October 2017 to December 2023 were enrolled in the study. Low-risk PTMC were detected by ultrasonogrphy in those subjects and ultrashonography was followed up to observe the changes of maximum diameter and volume of the tumor, and metastasis of cervical lymph nodes. The clinical characteristics and ultrasonic image features were compared between the subjects with the tumor growth and without tumor growth, and the influencing factors of tumor growth were analyzed.Results:Among 136 subjects with low-risk PTMC, there were 23 cases (16.9%) with tumor growth (growth group) and 113 cases (83.1%) without tumor growth (non-growth group). Cervical lymph node metastasis occurred in 8 cases (5.9%: 7 (30.4%) in the growth group and 1 (0.9%) in non-growth group), no distant metastasis were detected. There were significantly differences in patients age of initial diagnoisi, maximum diameter and volume of tumors between the growth group and non-growth group (all P<0.05). Logistic regression analysis showed that age of initial diagnoisi ≤40 years ( OR=4.299, 95% CI:1.662-12.175, P=0.003) was an independent risk factor for tumor growth and the maximum diameter of the initial examination was independent protective factor for tumor growth (increasing 1 mm of initial diameter: OR=0.554, 95% CI:0.317-0.969, P=0.038). Conclusion:The size of most low-risk PTMC detected by ultrasonography during the health check-up does not grow and the risk of cervical lymph node metastasis is low; however, for those with age of initial diagnoisi ≤40 years and smaller size tumor, the risk of PTMC growth would be increased.
