Correlation between CT attenuation value of pulmonary artery thrombi and efficacy of interventional thrombolysis in patients with acute pulmonary embolism
10.3760/cma.j.cn114798-20231031-00342
- VernacularTitle:肺动脉血栓CT值与急性肺栓塞介入溶栓治疗效果的相关性分析
- Author:
Xiaonan SUN
1
;
Zhongxiao LIU
;
He ZHANG
;
Xin TANG
;
Shenman QIU
;
Yankai MENG
;
Lixiang XIE
;
Shaodong LI
;
Qingqiao ZHANG
;
Kai XU
Author Information
1. 徐州医科大学附属医院医学影像科 徐州医科大学医学影像学院 江苏省医学影像与数字医学工程研究中心，徐州 221002
- Keywords:
Pulmonary embolism;
Thrombus;
CT number;
Qanadli embolism index
- From:
Chinese Journal of General Practitioners
2024;23(7):728-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between CT attenuation value of pulmonary artery thrombi and the efficacy of interventional thrombolysis in patients with acute pulmonary embolism (APE).Methods:This was a single center cross-sectional study. The clinical and imaging data of 89 APE patients who underwent interventional thrombolysis in Affiliated Hospital of Xuzhou Medical University from January 2018 to December 2022, were retrospectively analyzed. All patients underwent CT pulmonary angiography (CTPA) before and after thrombolysis, the CT attenuation value of pulmonary artery thrombi and ratio of CT attenuation value of thrombi to left subscapularis muscle CT value were obtained; and the difference of Qanadli embolism index (ΔQ) before and after thrombolysis was calculated. According to the median ΔQ, patients were classified as good efficacy group (ΔQ>50%) and poor efficacy group (ΔQ≤50%). The clinical characteristics and quantitative parameters of CT were compared between the two groups, and the factors associated with efficacy of thrombolysis were analyzed with univariate and multivariate logistic regression. The correlation between CT attenuation value of pulmonary artery thrombi and ΔQ was analyzed by Spearman correlation analysis.Results:The CT attenuation value of thrombi and ratio of attenuation value of thrombi to left subscapularis muscle CT value showed significant difference between the two groups ( P<0.05). Multivariate analysis showed that compared with CT attenuation value of emboli≤53.47 HU, the value>53.47 HU might be associated with the good efficacy of thrombosysis ( OR=9.175, 95% CI: 0.937-89.846, P=0.057). There was a positive correlation between CT value of pulmonary artery thrombi and ΔQ ( r=0.365, P<0.001). Conclusion:The CT attenuation value of thrombi can predict the efficacy of interventional thrombolysis in APE patients, and patients with higher CT attenuation value would have a better treatment response.
