Recent advance in clinical researches of islet organoids for treating type 1 diabetes mellitus
10.3760/cma.j.cn421203-20231103-00154
- VernacularTitle:胰岛类器官治疗1型糖尿病的临床研究进展
- Author:
Boya ZHANG
1
;
Xiangheng CAI
;
Shusen WANG
Author Information
1. 天津市第一中心医院 细胞移植科，天津 300384
- Keywords:
Diabetes mellitus type 1;
Islet transplantation;
Organoid;
Stem cell
- From:
Chinese Journal of Organ Transplantation
2024;45(9):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Type 1 diabetes mellitus (T1DM) is a multifactorial autoimmune disease and T1DM patients require insulin therapy. Capable of delaying the process of diabetic microangiopathy and lowering diabetes-related mortality, islet transplantation has become an ideal treatment of T1DM. However, islet transplantation is severely limited by an acute shortage of donor pancreas. In recent years, islet regeneration is gaining popularity. This review focused upon an overview of cell sources of islet organoids, optimization methods for islet organoids culture and research advances in clinical applications, providing references for clinical transformation of islet organoids for T1DM.
