Prognostic values of parameters from hypothermic machine perfusion after static cold storage on short-term outcomes of kidney transplantation
10.3760/cma.j.cn421203-20231227-00203
- VernacularTitle:静态冷保存序贯低温机械灌注参数对移植肾短期预后影响
- Author:
Tianying XING
1
;
Jiangtao WU
;
Qi WANG
;
Guangping LI
;
Ying HUANG
;
Tongwen OU
Author Information
1. 首都医科大学宣武医院泌尿外科，北京 100053
- Keywords:
Kidney transplantation;
Organ preservation;
Hypothermic machine perfusion
- From:
Chinese Journal of Organ Transplantation
2024;45(8):543-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prognostic values of parameters from hypothermic machine perfusion (HMP) after static cold storage (SCS) on short-term outcomes of kidney transplantation.Method:From February 2023 to October 2023, the authors retrospectively reviewed the clinical and HMP data of recipients undergoing adult deceased donor kidney transplantation at Xuanwu Hospital, Capital Medical University. HMP resistance and renal arterial anatomical variants were utilized for subgroup analysis. The primary endpoints were delayed graft function (DGF) and whether or not creatine level normalized. The secondary endpoints were the lowest creatine level within 1 month post-kidney transplantation, reduction extent of creatinine level, duration for creatine level to decline to the lowest and duration for creatinine normalization. Single and multiple variable analyses were utilized for examining the correlation between HMP parameters and short-term postoperative outcomes.Result:A total of 157 recipients were included for analysis. Mean serum creatinine level was (870.0±283.9) μmol/L and mean trough creatinine level within 1 month postoperatively (118.5±63.5) μmol/L. Sixteen recipients (10.2%) had delayed graft function (DGF) and creatinine failed to normalize in 10 receipients (6.4%). Average time for creatinine to decline to the lowest level within 1 month was (14.5±7.6) d (3~30 d) and average time for creatinine to normalize (6.4±5.8) d (1~30 d). Multiple variable regression analysis revealed that terminal resistant index was independently correlated with multiple events, including DGF ( P<0.01), whether or not creatinine level normalized within 1 month ( P=0.001), reduction extent of creatinine level ( P<0.01) and duration for creatinine normalization ( P=0.024) . Conclusion:Parameters of HMP after SCS are capable of predicting the short-term outcomes of kidney transplantation. Terminal resistant index is an independent risk factor for several prognostic events.
