Research advances in donor heart preservation of heart transplantation
10.3760/cma.j.cn421203-20231230-00206
- VernacularTitle:心脏移植供心保护研究进展
- Author:
Nianguo DONG
1
;
Zihao WANG
;
Yixuan WANG
Author Information
1. 华中科技大学同济医学院附属协和医院心脏大血管外科，武汉 430022
- Keywords:
Heart transplantation;
Organ preservation;
Machine perfusion;
Preservation solution
- From:
Chinese Journal of Organ Transplantation
2024;45(8):537-542
- CountryChina
- Language:Chinese
-
Abstract:
The techniques of heart preservation are applied during various stages of heart procurement, transportation and transplantation. Scientific and advanced preservations of donor hearts are essential for expanding the source of hearts and improving the outcomes of heart transplantation. Static cold preservation (SCS), as a classic preservation technique, is both economical and reliable in short-term heart transportation conditions. However, with the elapsing of preservation time, it may cause serious cold ischemic injuries and cannot timely monitor and intervene the status of heart. In recent years, some new preservation methods of donor hearts have been applied in clinical practices, including static temperature control system, normothermic machine perfusion and hypothermic machine perfusion. These technologies can effectively expand the source of hearts, prolong the transportation time of hearts and optimize the long-term outcomes of heart transplantation. This review summarized the latest researches of heart preservation techniques based upon the experience of our own center, providing theoretical rationales for heart transplantation preservation.
