Research progress in lymph node targeted drug delivery system for transplantation rejection
10.3760/cma.j.cn421203-20230620-00008
- VernacularTitle:淋巴结靶向药物递送系统治疗移植排斥反应研究进展
- Author:
Jiani QIU
1
;
Yishu SONG
;
Qiaofeng JIN
;
Ying BAI
;
Mingxing XIE
;
Jing WANG
Author Information
1. 华中科技大学同济医学院附属协和医院超声医学科，湖北省影像医学临床医学研究中心，分子影像湖北省重点实验室，武汉 430022
- Keywords:
Lymph node;
Transplantation rejection;
Targeted drug delivery system;
Immunosuppressant;
Active targeting;
Passive targeting
- From:
Chinese Journal of Organ Transplantation
2024;45(7):481-485
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressants are the most commonly used therapeutic means to reduce organ transplantation rejection and improve short-term clinical outcomes of patients after transplantation. However, systemic use of immunosuppressants increases the risk of opportunistic infections and the incidence of malignancies. Therefore, the efficient targeted delivery of immunosuppressants to target organs is particularly important. Lymph nodes are the main sites of transplant rejection activation. In recent years, drug delivery systems targeting lymph nodes have played an increasingly important role in the treatment of organ transplant rejection. This review briefly introduces the mechanism of action of lymph nodes in transplant rejection, and focuses on the construction of lymph node targeted drug delivery system and its application in transplant rejection, aiming to apply it in the treatment of transplant rejection toimprove patient outcomes.
