Research advances in immunosuppressant withdrawal and immune tolerance after pediatric liver transplantation
10.3760/cma.j.cn421203-20231120-00167
- VernacularTitle:儿童肝移植术后免疫抑制剂撤除策略与免疫耐受研究进展
- Author:
Wei GAO
1
;
Ruofan WANG
Author Information
1. 天津市第一中心医院儿童器官移植科天津市器官移植重点实验室，天津 300192
- Keywords:
Liver transplantation;
Child;
Immunosuppressant;
Immune tolerance
- From:
Chinese Journal of Organ Transplantation
2024;45(5):303-307
- CountryChina
- Language:Chinese
-
Abstract:
The most effective treatment for end-stage liver disease (ESLD) in children is liver transplantation (LT ). After LT, recipients must take immunosuppressants for a long time to maintain graft function. The side effects of immunosuppressants affect long-term recipient survival. Many domestic and global centers have made great efforts to taper or completely remove immunosuppressants in recipients in recent years. Some recipients successfully achieve immune tolerance after withdrawing immunosuppressants. However, there are no definite and effective protocols or indicators for immunization evaluation. And few studies focused upon the safety and long-term outcomes of immunosuppressant withdrawal. This review discussed the protocols and researches of immune tolerance after pediatric LT to provide practical guidance for a withdrawal of immunosuppressants and clinical advice of immune tolerance.
