Researches of nanotechnology in encapsulated islet grafts
10.3760/cma.j.cn421203-20231122-00170
- VernacularTitle:纳米技术在封装胰岛移植物中的研究
- Author:
Zitong YU
1
;
Weichen ZHANG
;
Ying CHENG
Author Information
1. 中国医科大学附属第一医院器官移植暨肝胆外科，沈阳 110002
- Keywords:
Nanotechnology;
Islet transplantation;
Islet encapsulation;
Immune isolation
- From:
Chinese Journal of Organ Transplantation
2024;45(3):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Islelet transplantation (IT) is an ideal treatment for type 1 diabetes. However, a large number of transplanted islet cells become lost due to immune responses and other reasons, resulting in a poor long-term efficacy of IT. Islet encapsulation is wrapping islet cells with semi-permeable materials for protecting insulin secretion function by islet cells, reducing islet cell apoptosis and minimizing immune responses. Nanotechnology enables a nanoscale control of encapsulated materials. A better "isolation" of islet cells and external environment is essential for prolonging the survival time of islet cells. This review summarized the advantages and disadvantages of different nanotechnologies in encapsulating IT for the goals of prolonging the survival of islet cells, improving insulin secretion and boosting the efficacy of IT.
