Applications of organ medicine and organ isolation protection therapy based upon normothermic machine perfusion in different research fields
10.3760/cma.j.cn421203-20240115-00012
- VernacularTitle:基于常温机械灌注的器官医学及器官隔离保护治疗在不同研究领域中的应用
- Author:
Jiang QIU
1
;
Haiwei CHEN
;
Shuangjin YU
Author Information
1. 中山大学附属第一医院器官移植中心，广州 510080
- Keywords:
Normothermic machine perfusion;
Organ preservation;
Organ medicine;
Organ-quarantined therapy
- From:
Chinese Journal of Organ Transplantation
2024;45(3):162-166
- CountryChina
- Language:Chinese
-
Abstract:
Normothermic machine perfusion (NMP) is currently a research hotspot of organ preservation in the field of transplantation. Its safety and effectiveness of organ preservation have been clinically validated especially for preserving marginal donor organs. Various unique advantages of NMP are offered for in vitro organ function assessments, maintenance and organ injury repairing. Within the field of organ medicine, precise clinical interventions based upon in vivo or in vitro researches are implemented through an in vitro organ support system. With an aid of extracorporeal organ support system, an independent extracorporeal circulation system could be established for single or multiple organs more efficiently and safely. And physiological supports and other interventions for target organs are performed. Organ gene editing therapy, organ cell therapy, organ chemotherapy, organolytic virus therapy and organ physiological support therapy are all disciplines of organ quarantine therapy. This emerging theory provides a novel treatment for clinical organ diseases. This review summarized the use of NMP technology based upon the concepts and applications of organ medicine. Also the applications of organ isolation and protection therapy were discussed for organ transplantation and other research fields.
