Research advances of bioartificial kidney in the management of renal failure
10.3760/cma.j.cn421203-20230824-00059
- VernacularTitle:生物人工肾在肾衰竭研究中的进展
- Author:
Zejiaxin NIU
1
;
Tian WEI
;
Bingxuan ZHENG
;
Puxun TIAN
Author Information
1. 西安交通大学第一附属医院肾脏病医院肾移植科西安交通大学器官移植研究所，西安 710061
- Keywords:
Renal failure;
Renal replacement therapy;
Artificial kidney;
Hemofiltration;
Bioreactor
- From:
Chinese Journal of Organ Transplantation
2024;45(2):125-130
- CountryChina
- Language:Chinese
-
Abstract:
Renal failure has been a common disease of seriously affecting human health and incurring huge medical expenses. Renal function replacement therapy is a major treatment of renal failure. However, hemodialysis, peritoneal dialysis has many limitations in clinical practices. Due to a great shortage of organs, kidney transplantation is not widely applied for end-stage renal disease. In recent years, bioartificial kidney has emerged as a promising alterative. Blood filters of replacing glomerular filtration and bioreactors of mimicking tubular function are combined for replace most functions of filtration, reabsorption, secretion and metabolism of the kidney. This review summarized the latest advances of globally cutting-edge bioartificial kidney devices, including silicon nanotechnology, tissue engineering and dialysate regeneration technology. filtration membrane of blood filter, biological carrier membrane of bioreactors and in vitro culturing of renal tubular cells. It is expected that bioartificial kidney may be applied more extensively for RF.
