assisted clearance of early high-level donor specific antibody after kidney transplantation through splenic radiotherapy: one case report
10.3760/cma.j.cn421203-20230726-00035
- VernacularTitle:脾脏放射治疗辅助清除肾移植后早期高水平供者特异性抗体1例
- Author:
Wang ZHENG
1
;
Zhiliang GUO
;
Rula SA
;
Guangyuan ZHAO
;
Daqiang ZHAO
;
Lan ZHU
;
Gang CHEN
Author Information
1. 中南大学湘雅医学院附属常德医院器官移植科，常德 415000
- Keywords:
Kidney transplantation;
Donor specific antibody;
Radiotherpy;
Antibody-mediated rejection
- From:
Chinese Journal of Organ Transplantation
2024;45(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
This report described one human leukocyte antigen pre-sensitized recipient undergoing preoperative plasmapheresis (PP), intravenous immunoglobulins (IVIG) desensitization and immune induction therapy before kidney transplantation with a donor kidney. Early postoperative clinical diagnosis was acute antibody-mediated rejection (AMR). A marked elevation of donor-specific antibodies (DSA) was accompanied by a decline of renal function. PP/IVIG dosing failed to lower the level of DSA. After low-dose splenic irradiation, DSA level dropped steadily and transplanted kidney function normalized. Thus adjuvant low-dose splenic irradiation may eliminate DSA immediately without a rebound.
