Tumor deposit is an independent prognostic factor in patients with gastric cancer after radical gastrectomy
10.3760/cma.j.cn113855-20240815-00539
- VernacularTitle:癌结节对根治切除术后胃癌患者预后的影响
- Author:
Liquan ZHOU
1
;
Yushi ZHOU
;
Qiwei XIE
;
Yingjiang YE
;
Bin LIANG
Author Information
1. 北京大学人民医院胃肠外科，北京 100044
- Keywords:
Stomach neoplasms;
Prognosis;
Risk factos;
Tumor deposit
- From:
Chinese Journal of General Surgery
2024;39(10):790-796
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of tumor deposit(TD) on the prognosis of patients with gastric cancer after radical surgery.Methods:A retrospective analysis was performed on gastric cancer patients who underwent radical surgery at the Department of Gastrointestinal Surgery, Peking University People's Hospital from Jan 2021 to Dec 2023. The relationship between the status of tumor deposit and clinicopathological features, as well as the impact on the overall postoperative survival of gastric cancer patients were evaluated.Results:Pathological examination revealed that among 212 patients with gastric cancer, 12 patients (5.1%) had tumor deposits (TD). The occurrence of TD was found to be associated with preoperative T stage, N stage, and extramural vascular invasion (EMVI) (all P<0.05). During the follow-up period, 31 patients experienced recurrence, metastasis, or death. The COX multivariate analysis indicated that N stage ( P=0.07), preoperative serum CEA level ( P<0.001), EMVI ( P=0.001), and TD ( P=0.011) were independent risk factors affecting the overall postoperative survival . Among patients who received neoadjuvant therapy and on pT4 stage, pN+ status, and EMVI status before surgery, the presence of TD was closely correlated with overall survival. Patients with TD had a worse prognosis and shorter overall survival( P<0.05). Conclusion:Tumor deposit is an important risk factor affecting the prognosis of patients after radical gastrectomy and may be a predictive biomarker of early peritoneal metastasis.
