Influencing factors of liver regeneration after full-size split liver transplantation
10.3760/cma.j.cn113855-20240331-00238
- VernacularTitle:完全劈离式肝移植术后肝再生影响因素研究
- Author:
Yuhao DU
1
;
Yuying SHAN
;
Shuqi MAO
;
Changjiang LU
;
Shengdong WU
;
Jing HUANG
;
Jiongze FANG
;
Caide LU
Author Information
1. 宁波大学附属李惠利医院肝胆胰外科，宁波 315041
- Keywords:
Liver transplantation;
Liver regeneration
- From:
Chinese Journal of General Surgery
2024;39(9):692-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the factors influencing recipient liver regeneration after full-size split liver transplantation (fSLT).Methods:The clinical data of patients undergoing split liver transplantation in the Affiliated Li Huili Hospital of Ningbo University from May 2019 to Sep 2023 were retrospectively collected. Graft volume (GV) and initial graft volume (IGV) at (30±7) days after operation were measured, and postoperative liver regeneration rate (LRR) was calculated. The patients undergoing fSLT were divided into high regeneration group and low regeneration group with LRR=30% as boundary. The differences of donor and recipient data and perioperative data between the two groups were compared.Results:A total of 52 patients were included. The low fSLT regeneration group (16 cases) was compared with the high fSLT regeneration group (36 cases), and in high fSLT regeneration group donor age was lower, the donor liver steatosis was less, GRWR was lower, the incidence of hepatitis B virus-related liver disease was lower, the postoperative diagnosis of malignant liver disease was lower, the intraoperative blood loss was less, and the postoperative platelet count was higher. The levels of liver enzyme and total bilirubin (TBiL) were higher than those in high regeneration group ( P<0.05). Conclusions:Donor age, donor liver steatosis, GRWR, hepatitis B virus associated liver disease, and recipient pathogenesis are important factors affecting liver regeneration after fSLT. Postoperative platelet and liver enzyme levels are important indicators for monitoring liver regeneration after fSLT.
