Pancreaticoduodenectomy for duodenal papillary carcinoma:tumor size and lymph node metastasis affect long-term survival
10.3760/cma.j.cn113855-20240328-00231
- VernacularTitle:胰十二指肠切除术治疗十二指肠乳头癌—肿瘤大小和淋巴结转移影响术后长期生存
- Author:
Xiao CUI
1
;
Zicheng GUO
;
Hong XUE
;
Sheng WEI
;
Yongfan LIU
;
Xiaoping GENG
;
Yan HUANG
;
Hui HOU
Author Information
1. 安徽医科大学第二附属医院普外科，合肥 230000
- Keywords:
Pancreaticoduodenectomy;
Prognosis;
Duodenal papillary carcinoma;
Lymph node metastasis
- From:
Chinese Journal of General Surgery
2024;39(9):686-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological factors affecting the long-term survival of patients with duodenal papillary carcinoma (DPC) after pancreaticoduodenectomy (PD).Methods:The clinicopathological and follow-up data of patients with DPC who underwent PD at the First Affiliated Hospital of Anhui Medical University and the Second Hospital of Anhui Medical University from Jan 2015 to Dec 2021 were retrospectively analyzed.Results:All 73 cases have been followed-up. The median follow-up time was 60 months. Multivariate analysis of COX proportional risk model showed that positive lymph node metastasis and tumor size over 2.5 cm were common independent risk factors for OS and DFS. Lymph node metastasis was confirmed pathologically in 20 patients. Multivariate analysis results of Logistic regression model showed that smoking, tumor breaking through the serous layer and tumor low differentiation were independent risk factors for lymph node metastasis.Conclusions:Poor prognosis was associated with tumors that were larger than 2.5 cm, and with lymph node metastases. Preoperative smoking history, tumor breaking through the serous layer and low tumor differentiation were the predictors of positive lymph node metastasis.
