Plasma ghrelin concentration on postoperative complications and nutritional status in patients with gastric cancer
10.3760/cma.j.cn113855-20230720-00013
- VernacularTitle:胃癌患者血浆胃促生长素浓度对术后并发症及营养状况的预测价值
- Author:
Weikang LI
1
;
Kaipeng DUAN
;
Dongbao LI
;
Jiayu REN
;
Xiaotong SUN
;
Lixing GU
;
Jin ZHOU
Author Information
1. 苏州大学附属第一医院普通外科，苏州 215006
- Keywords:
Stomach neoplasms;
Nutrition assessment;
Ghrelin;
Postoperative complications
- From:
Chinese Journal of General Surgery
2024;39(8):615-619
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of neuroendocrine function on postoperative complications and nutritional status in gastric cancer patients.Methods:Clinical data of 102 gastric cancer patients who underwent radical gastrectomy at the Department of General Surgery, First Affiliated Hospital of Soochow University, from Aug 2021 to Jun 2022 were retrospectively analyzed.Results:Among the 102 gastric cancer patients, 18 (17.6%) suffered from postoperative complications. Univariate analysis indicated that age, BMI, preoperative plasma ghrelin concentration, and preoperative hemoglobin levels were associated with early postoperative complications following radical gastrectomy. Multivariate analysis revealed that age, BMI, and preoperative plasma ghrelin concentration ( P<0.05) were independent risk factors for postoperative complications in gastric cancer patients. Differential analysis of ghrelin concentration demonstrated correlations with hemoglobin levels, skeletal muscle index, albumin, and creatinine, and a positive correlation with the skeletal muscle index. Conclusions:Reduced preoperative neuroendocrine hormone ghrelin concentration is an independent risk factor for postoperative complications in gastric cancer patients. Ghrelin concentration is correlated with the skeletal muscle index in these patients.
