Predictive value of Naples prognostic score on long-term outcome in patients with intrahepatic cholangiocarcinoma
10.3760/cma.j.cn113855-20231023-00263
- VernacularTitle:Naples预后评分在肝内胆管癌患者长期生存中的预测价值
- Author:
Hang JIANG
1
;
Xing CHEN
;
Jia WU
;
Fang HAN
;
Chao HU
;
Linwei XU
;
Jiangshu LIU
;
Yuhua ZHANG
Author Information
1. 浙江中医药大学第二临床医学院，杭州 310053
- Keywords:
Cholangiocarcinoma;
Survival rate;
Naples prognostic score;
Area under the curve
- From:
Chinese Journal of General Surgery
2024;39(8):609-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of Naples prognostic score (NPS) in assessing the overall survival of intrahepatic cholangiocarcinoma (ICC) patients after receiving hepatectomy treatment.Methods:Clinicopathological characteristics and follow-up data of 164 ICC patients who underwent curative hepatectomy at Zhejiang Cancer Hospital from Jan 2010 to Aug 2022 were retrospectively collected. NPS was calculated basing on preoperative serum albumin concentration, total cholesterol concentration, the neutrophil-lymphocyte ratio, and lymphocyte-monocyte ratio. The relationship between NPS and overall survival was analyzed, and the efficacy of NPS in predicting long-term survival was compared to TNM staging system and other independent risk factors.Results:Multivariate analysis identified the NPS [Score 1 versus 0: 1.864 (1.011-3.437), P=0.046; Score 2 versus 0: 3.013 (1.465-6.199), P=0.003] as an independent risk factor for overall survival. The area under curve (AUC) of the rece中iver operating characteristic (ROC) curve for predicting 5-year OS based on NPS is 0.75, which is higher than TNM staging (0.59) and other independent risk factors (CA19-9:0.71, lymph node metastasis: 0.66, tumor size: 0.62, microvascular invasion: 0.56). Conclusion:NPS as an independent predictor of overall survival for ICC patients, is more accurate than TNM staging system and other clinicopathological factors.
