Risk factors and distribution characteristics for skip metastasis in papillary thyroid carcinoma
10.3760/cma.j.cn113855-20230404-00172
- VernacularTitle:甲状腺乳头状癌淋巴结跳跃性转移危险因素及分布特征分析
- Author:
Changjiao YAN
1
;
Meiling HUANG
;
Jingjing XIAO
;
Rui LING
Author Information
1. 空军军医大学西京医院甲乳血管外科，西安 710032
- Keywords:
Thyroid neoplasms;
Lymphatic metastasis;
Carcinoma, papillary;
Risk factor
- From:
Chinese Journal of General Surgery
2024;39(7):544-549
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors and distribution characteristics for skip lateral lymph node metastasis in patients of papillary thyroid carcinoma (PTC).Methods:Clinical data of 720 PTC patients with postoperative pathologically confirmed lymph node metastasis in the lateral cervical region at Xijing Hospital of Air Force Military Medical University from Jan 2014 to Dec 2021 were retrospectively analyzed. According to whether there is skip metastasis in the lymph nodes of the patients, patients were divided into skip metastasis group (92 cases) and non-skip metastasis group (628 cases).Results:The rate of lymph node skip metastasis in PTC in this study was 12.7% (92/720). Women ( OR=1.890, 95% CI:1.118-3.198, P=0.018), age ≥55 years ( OR=2.508, 95% CI:1.412-4.454, P=0.002), tumor involving the upper pole ( OR=1.919, 95% CI:1.220-3.018, P=0.005), and unilateral glandular lobe lesions ( OR=1.926, 95% CI:1.153-3.214, P=0.012) were independent risk factors for lymph node skip metastasis. Skip metastasis is most likely to occur in region Ⅲ, followed by region Ⅵ, Ⅱ and Ⅴ. Larger cancer tended to have more than one jumping metastases in regions Ⅲ and Ⅳ ( P=0.001, 0.016). Conclusion:In female PTC patients, age≥55 years , tumors involving upper pole, and unilateral lesions,are all the hazardous factor for skip metastasis in the lateral neck region.
