The effectiveness of prolonged antibiotic use in preventing surgical site infections after hepatectomy
10.3760/cma.j.cn113855-20231210-00401
- VernacularTitle:抗生素使用时间与预防肝切除术后手术部位感染效果的相关性分析
- Author:
Zhenhua BAI
1
;
Xiangde SHI
;
Qibin TANG
;
Xianhuan YU
;
Rui ZHANG
;
Chao LIU
Author Information
1. 中山大学孙逸仙纪念医院胆胰外科，广州 510288
- Keywords:
Hepatectomy;
Surgical site infection;
Antibiotic prophylaxis;
Risk factor
- From:
Chinese Journal of General Surgery
2024;39(7):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effectiveness of antibiotics in preventing surgical site infection (SSI) after hepatectomy.Methods:The clinical data of patients who underwent hepatic resection at the Department of Biliary and Pancreatic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, from Jan 2019 to Dec 2021, were retrospectively analyzed.Results:A total of 509 patients were included in the study. There was no statistically significant difference in the incidence of SSI in the different prophylactic treatment time groups ( P>0.05). Univariate analysis revealed bile leakage, extent of hepatic resection, surgical procedure, level of anesthesia, and duration of surgery as potential risk factors for SSI after hepatic resection ( P<0.05); Multivariate analysis showed that bile leakage, extensive hepatic resection, open surgical approach, grade 3-4 anesthesia level, and operative time longer than 300 minutes might be independent risk factors affecting SSI after hepatectomy ( P<0.05). Conclusion:Prolonging antibiotic prophylaxis for SSI after hepatectomy may be unnecessary.
