Expression of PD-L1/B7-H3 in intrahepatic cholangiocarcinoma and its correlations with clinicopathological features and prognosis
10.3760/cma.j.cn113855-20240120-00053
- VernacularTitle:PD-L1/B7-H3在肝内胆管癌中的表达及其与临床病理及预后的关系
- Author:
Jie ZHANG
1
;
Bin JIANG
;
Lingfu ZHANG
;
Chunhui YUAN
;
Xiaofeng LING
;
Dianrong XIU
Author Information
1. 北京大学第三医院普通外科，北京 100191
- Keywords:
Cholangiocarcinoma;
Immunohistochemistry;
PD-L1;
B7-H3;
Prognosis
- From:
Chinese Journal of General Surgery
2024;39(6):476-481
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of PD-L1 and B7-H3 in intrahepatic cholangiocarcinoma (ICC) and their relationship with the prognosis after surgery.Methods:Clinicopathological data of 63 ICC patients undergoing surgery at the Department of General Surgery, Peking University Third Hospital, from Sep 2016 to Mar 2023 were retrospectively analyzed.Results:PD-L1 and B7-H3 are highly expressed in 41.3% and 60.3% of ICC patients, respectively, and their expression levels were positively correlated with each other( P=0.005). High PD-L1 expression is significantly associated with poor tumor differentiation ( P=0.014), while high B7-H3 expression is significantly related to lymph node metastasis ( P=0.035). In patients with high co-expression of PD-L1 and B7-H3, the overall survival ( P=0.031) and recurrence-free survival ( P=0.031) were significantly decreased. High co-expression of PD-L1 and B7-H3 is an independent risk factor for recurrence in ICC ( HR=3.998, 95% CI: 1.211-13.198; P=0.023). Conclusions:ICC patients with high expression of both PD-L1 and B7-H3 have a poor prognosis. Using both as the combined biomarker significantly improves the prediction of long-term survival after surgery, compared to using either one alone.
