Prognostic factors of liver transplantation for hepatocellular carcinoma recipients beyond UCSF criteria but without macrovascular invasion
10.3760/cma.j.cn113855-20240121-00055
- VernacularTitle:超UCSF标准且无大血管侵犯的肝细胞癌肝移植的预后危险因素分析
- Author:
Guangdong WU
1
;
Rui TANG
;
Ang LI
;
Xuan TONG
;
Lihan YU
;
Yucheng HOU
;
Abudusalamu AINI
;
Wei YANG
;
Huayuan HAO
;
Jingyi LIN
;
Qian LU
Author Information
1. 清华大学附属北京清华长庚医院肝胆胰中心 清华大学临床医学院 数智肝胆病学教育部重点实验室，北京 102218
- Keywords:
Carcinoma,hepatocellular;
Liver transplantation;
Risk factors
- From:
Chinese Journal of General Surgery
2024;39(5):339-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic factors for liver transplantation for hepatocellular carcinoma beyond UCSF criteria but without macrovascular invasion.Methods:A retrospective analysis was performed for the clinical data of the hepatocellular carcinoma patients without macrovascular invasion beyond UCSF criteria who underwent liver transplantation at our center from Jan 2018 to Jun 2023. The receiver operating characteristic curve analysis was performed to assess the predictive power of potential prognosis factors.Results:With this criteria, the 1-, 3-year overall survival rates were 94.1% and 75.0%, respectively, and the 1-, 3-year tumor free survival rates were 82.4% and 38.1%, respectively. The maximum tumor size, number of tumors, AFP, PIVKA-Ⅱ before transplantation, and whether undergo pretransplant down-stage therapy were significant prognostic factors ( P<0.05). Combining the above prognostic factors to construct the receiver operating characteristic curve yielded an area under the curve of 0.967, with a sensitivity and specificity of 0.932, 0.952, respectively. Further, the differentiation, MVI and Ki-67 were significant prognostic factors ( P<0.05). Combining pathological factors to construct the receiver operating characteristic curve yielded an area under the curve of 0.927, with a sensitivity and specificity of 0.769, 1, respectively. Conclusion:The maximum tumor diameter, number of tumors, AFP, PIVKA-Ⅱ before transplantation, and pretransplant down-stage therapy and tumor differentiation, MVI and Ki-67 are all prognostic factors of liver transplantation for hepatocellular carcinoma without macrovascular invasion beyond UCSF criteria.
