Single-center experience on 1 147 cases of liver transplantation
10.3760/cma.j.cn113855-20240120-00051
- VernacularTitle:1 147例肝移植单中心经验
- Author:
Xiaopeng XIONG
1
;
Qingguo XU
;
Xiaolong MIAO
;
Hao WANG
;
Peng LIU
;
Xinqiang LI
;
Xin ZHOU
;
Xin WANG
;
Feng WANG
;
Yong ZHANG
;
Yandong SUN
;
Jinzhen CAI
;
Liqun WU
;
Chuanshen XU
;
Jianhong WANG
;
Qingjun GUO
Author Information
1. 青岛大学附属医院器官移植中心，青岛 266000
- Keywords:
Liver transplantation;
Prognosis;
Postoperative complications
- From:
Chinese Journal of General Surgery
2024;39(5):333-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prognostic outcomes of 1 147 patients who underwent liver transplantation at Qingdao University Affiliated Hospital and to summarize measures to enhance the efficacy of liver transplantation.Methods:A retrospective analysis was conducted on the clinical and follow-up data of 1 147 liver transplant patients at Qingdao University Affiliated Hospital.Results:The overall postoperative 1-, 3-, and 5-year survival rates for the 1 147 liver transplant patients were 87.20%, 73.40%, and 65.60%, respectively. The survival rates for benign disease liver transplant recipients were 88.01%, 84.98%, and 81.39% at 1, 3, and 5 years post-transplant, respectively, compared to recipients transplanted for malignancies of 78.11%, 64.41%, and 60.06% (all P<0.001). Among the mid vs more recent period, patients' 1-year and 3-year postoperative survival rates were 84.20%, 70.80% vs 90.50%, 71.70%, respectively,significantly in favor of recently enrolled patients ( P=0.022). In the complex surgery group, patients' 1-, 3-, and 5-year survival rates were 82.70%, 65.50%, 56.70%, while in less complicated group, it was 89.00%, 76.50%, 69.20% ( P<0.001). The primary causes of death for benign disease recipients were multi-organ failure (4.1%), while in recipients with malignant disease primary cause of death was tumor recurrence (23.7%). Postoperative complications included primary graft dysfunction, delayed graft function recovery, portal vein thrombosis, hepatic artery thrombosis, biliary stricture, post-transplant lymphoproliferative disorder, and graft-versus-host disease, with occurrence rates of 1.05%, 6.89%, 1.92%, 0.44%, 2.00%, 0.61%, and 0.44%, respectively. Conclusions:With the continuous improvement in surgical techniques and perioperative care levels, the 3-year survival rate of recipients at our center has increased. Malignant diseases and complex liver transplantation remain crucial factors affecting recipient prognosis, highlighting the need to further enhance comprehensive treatment capabilities for patients with malignant diseases and complex surgeries.
