A case of nonbullous neutrophilic lupus erythematosus
10.35541/cjd.20230213
- VernacularTitle:非大疱性嗜中性红斑狼疮1例
- Author:
Ruixia WANG
1
;
Yanlei QU
;
Wenjin AI
;
Lin YAN
;
Caijie QU
;
Tongxin SHI
Author Information
1. 青岛市市立医院皮肤科，青岛 266011
- Keywords:
Lupus erythematosus, cutaneous;
Non-bullous neutrophilic lupus erythematosus;
Skin manifestations;
Pathologic processes;
Therapy
- From:
Chinese Journal of Dermatology
2024;57(9):832-834
- CountryChina
- Language:Chinese
-
Abstract:
To report a case of nonbullous neutrophilic lupus erythematosus. A 57-year-old male patient presented with recurrent erythematous pruritic papules and plaques on the trunk and extremities for over 10 years. Skin examination revealed scattered urticaria-like papules and plaques on the trunk and limbs, with thin scales on the edge of some lesions. Laboratory tests showed positive antinuclear antibodies at a titer of 1∶320 (granular type), anti-Sj?gren syndrome A (SSA) antibodies (++), anti-SSB antibodies (+++), anti-Ro-52 antibodies (+++), and anti-neutrophil cytoplasmic antibodies at a level of 369.09 RU/ml (reference range: 0 - 20 RU/ml). Histopathological analysis of the skin lesions on the back revealed epidermal hyperkeratosis in a basket-like shape, liquefaction degeneration of basal cells, infiltration of numerous neutrophils in the superficial dermis with karyorrhexis, perivascular infiltration of lymphocytes in the superficial and middle dermis, and extensive extracellular mucin deposition throughout the dermis. Finally, the patient was diagnosed with nonbullous neutrophilic lupus erythematosus.
