Influence Factors of Lymphovascular Space Invasion in Low-grade Endometrioid Carcinoma of Uterus
10.3969/j.issn.1009-6604.2024.08.001
- VernacularTitle:子宫低级别子宫内膜样癌淋巴脉管间隙浸润的影响因素
- Author:
Min HAO
1
;
Xiaodan ZHENG
;
Xuejing WEI
Author Information
1. 首都医科大学附属北京友谊医院妇产科,北京 100050
- Keywords:
Endometrial carcinoma;
Low-grade;
Endometrioid carcinoma;
Lymphovascular space invasion
- From:
Chinese Journal of Minimally Invasive Surgery
2024;24(8):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence factors of lymphovascular space invasion(LVSI)in patients with low-grade endometrioid carcinoma.Methods Clinical data of 167 patients with low-grade(G1,G2)endometrioid carcinoma of uterus diagnosed by surgical pathology from January 2015 to May 2023 were retrospectively analyzed.Univariate analysis of the following 9 indicators was performed:age,postmenopausal status,abnormal vaginal bleeding duration,combined with metabolic syndrome,increased CA125(≥ 35 U/ml),endometrial thickness,uterine occupation,combined with adenomyosis of uterus,stage of the International Federation of Gynecology and Obstetrics(FIGO)2009 standards.The binary logistic refression analysis was made on factors with P＜0.05.Results Among the 167 patients with low-grade endometrioid carcinoma of uterus,24 cases(14.4％)had LVSI.The binary logistic regression analysis was performed for 4 factors(abnormal vaginal bleeding duration ≥ 4 months,increased CA125,combined with adenomyosis of uterus,stage Ⅱ and above)with P＜0.05 in the univariate analysis,and the results showed stage Ⅱ and above(OR=7.357,95％CI:2.140-25.288,P=0.002)and increased CA125(OR=4.883,95％CI:1.612-14.794,P=0.005)were an independent prognostic factor for LVSI in low-grade endometrial carcinoma of uterus.Conclusion Stage Ⅱ(FIGO 2009)and above and CA125≥35 U/ml are associated with LVSI in patients with low-grade endometrioid carcinoma,indirectly suggesting the risk of lymph node metastasis,which should be paid close attention to before surgery in order to develop a more accurate surgical plan.
