Effect of Sulfhydryl Compounds on Melanosomal Morphology of Epidermal Melanocytes in UV - Irradiated Black Mice.
- Author:
Kyung Won HAN
;
Ki Bum MYUNG
;
Jeong Hee HAHM
;
Hong Il KOOK
- Publication Type:Original Article
- Keywords:
Sulfhydryl compounds;
Glutathione;
Cysteine;
Melanosome;
Melanocyte;
Mice
- MeSH:
Animals;
Axis, Cervical Vertebra;
Cysteine;
Glutathione;
Injections, Intraperitoneal;
Melanocytes*;
Melanosomes;
Mice*;
Skin;
Sulfhydryl Compounds*
- From:Korean Journal of Dermatology
1987;25(5):553-561
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The present study was performed to evaluate the effect of sulfhydryl compounds, cysteine and glutathione, on the size of melanosomes and the ratio of melanosormai stages of epidermal melanocytes in UV-irradiated black mice. The results were as follows; 1. Both of cysteine and glutathione showed significant diminution in the short axis of melanosomes and the percentage of stage 4 melanosomes of epidermal melanocytes in C57BL black mice skin. 2. The length of short axis of melanosomes in glutathione-treated group is smaller than those in cysteine-treated group at the end of 3rd week of intraperitoneal injection. The percentage of stage IV melanosomes significantly decreased in glutathione-treated group and cysteine-treated group at the end of 3rd week and 5th week respectively. 3. In glutathione-treated group, the short axis of melanosomes and the percentage of stage 4 melanosomes both decreased in proportional to the period of intraperitoneal in]ection.
