Chemical constituents from the branches and leaves of Toona ciliata var pubescens and their antitumor activities
10.3969/j.issn.1001-1528.2024.11.022
- VernacularTitle:毛红椿枝叶化学成分及其抗肿瘤活性研究
- Author:
Ge-Zhou LIU
1
;
Wei-Dong PAN
;
Jin-Yu LI
;
Hua-Yong LOU
;
Han-Fei LIU
;
Kai-Qin LIN
Author Information
1. 贵州医科大学药学院/省部共建药用植物功效与利用国家重点实验室,贵州 贵阳 550014
- Keywords:
Toona ciliata Roem.var.pubescens(Franch.)Hand.-Mazz.;
branches and leaves;
chemical constituents;
isolation and identification;
antitumor activities
- From:
Chinese Traditional Patent Medicine
2024;46(11):3676-3682
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the branches and leaves of Toona ciliata Roem.var.pubescens(Franch.)Hand-Mazz.and their antitumor activities.METHODS The compounds were isolated and purified by silica gel,RP-18 reverse phase silica gel and semi-preparative HPLC,the structures of compounds were identified by physicochemical properties and spectral data.The antitumor activities were determined by MTT method.RESULTS Fifteen compounds were isolated and identified as toonaolide D(1),toonaciliatin E(2),bourjotinolone A(3),(21R,23R)-epoxy-21α-ethoxy-24S,25-dihydroxyapotirucalla-7-en-3-one(4),(Z)-toonasterone C(5),(E)-toonasterone(6),3-epi-dyscusin C(7),(Z)-aglawone(8),(E)-volkendousin(9),8(14),15-isopimaradiene-2α,3α,19-triol(10),(-)-loliolide(11),cyclohexenone(12),pubinernoid A(13),quercetin-3-O-(4″-methoxy)-α-L-rahmnopyranosyl(14),5-hydroxymethyl-2-furancarboxaldehyde(15).The IC50 values of compounds 3 and 4 on K562 cells were 54.2 and 47.3 μmol/L,respectively,and the IC50 values on HEL cells were 47.3 and 61.1 μmol/L,respectively.CONCLUTION Compounds 4,7,10 and 11 are isolated from Toona genus for the first time,and compounds 2,15 are first isolated from this plant.Compounds 3 and 4 show weak antitumor activities.
