Chemical constituents from n-butanol fraction of Corydalis impatiens and their antioxidant activities
10.3969/j.issn.1001-1528.2024.11.021
- VernacularTitle:赛北紫堇正丁醇部位化学成分及其抗氧化活性研究
- Author:
Chao-Fan DENG
1
;
Ze-Dong NAN
;
Zhen-Zhen WANG
;
Jing-Ling YANG
;
Zhen-Yu AN
;
Xiu-Li WU
;
Xiao-Li MA
;
Zhi-Bo JIANG
Author Information
1. 北方民族大学化学与化学工程学院,国家民委化工技术重点实验室,宁夏 银川 750021
- Keywords:
Corydalis impatiens(Pall.)Fisch.;
n-butanol fraction;
chemical constituents;
isolation and identification;
antioxidant activities
- From:
Chinese Traditional Patent Medicine
2024;46(11):3671-3676
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from n-butanol fraction of Corydalis impatiens(Pall.)Fisch.and their antioxidant activities.METHODS The n-butanol fraction was isolated and purified by silica gel,MCI,ODS,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The antioxidant activities were determined by DPPH method and tyrosinase method.RESULTS Fourteen compounds were isolated and identified as nicotinamide(1),methyl L-pyroglutamate(2),bungeanoline F(3),monomethyl fumarate(4),5-hydroxymethylfurfural(5),4-hydroxybenzoic acid(6),hydroxybenzoate(7),methyl 3,4-dihydroxybenzoate(8),methyl ferulate(9),dimethylcaffeic acid(10),dimethyl feruloyl malate(11),(-)-4-O-feruloylquinic acid(12),syringaresinol(13)and(-)-loliolide(14).Compounds 1,8,11 and 13 showed strong antioxidant activites on DPPH free radicals,with IC50 values ranging from 54.47 to 97.4 μmol/L.Compound 13 had potential inhibitory effect on tyrosinase.CONCLUSION Compounds 4-14 are first isolated from Corydalis genus,and 3 is isolated from this plant for the first time.Compounds 1,8,11 and 13 have strong antioxidant activities.
