Clinical effects of comprehensive treatment regimen of traditional Chinese medicine on patients with refractory rhinosinusitis
10.3969/j.issn.1001-1528.2024.11.016
- VernacularTitle:中医综合治疗方案对难治性鼻窦炎患者的临床疗效
- Author:
Qun-Zhen LI
1
;
Jun LI
;
Zhong-Yi MIAO
;
Shao-Xi FAN
;
Ru YAN
;
Feng-Mei MA
;
Ting RONG
Author Information
1. 河北省中医院,河北 石家庄 050011
- Keywords:
Xinzhi Tongqiao Granules;
Xinbai Nasal Fumigation Powder;
sphenopalatine ganglion;
refractory sinusitis
- From:
Chinese Traditional Patent Medicine
2024;46(11):3645-3650
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of comprehensive treatment regimen of traditional Chinese medicine on patients with refractory rhinosinusitis.METHODS One hundred and sixty-four patients were randomly assigned into control group(82 cases)for 3-month intervention of comprehensive treatment regimen of western medicine(Physiological Seawater Nasal Spray,Budesonide Nasal Spray,Clarithromycin Tablets),and observation group(82 cases)for 3-month intervention of comprehensive treatment regimen of traditional Chinese medicine(Xinzhi Tongqiao Granules,Xinbai Nasal Fumigation Powder,acupuncture of sphenopalatine ganglion).The changes in clinical effects,subjective disease indices(clinical symptom scores,SNOT-20 score,Lung Meridian Heat Accumulation Syndrome score),objective disease indices(Lund-Kennedy score,T&T olfactory score,MTT,MTR),inflammatory indices(LTC4,IL-17a,IL-33,ECP),immune indices(CD4+,CD8+,Treg,Th17,CD4+/CD8+,Th17/Treg)and safety indices were detected.RESULTS The observation group demonstrated higher total control rate than the control group(P＜0.05).After the treatment and at 3-month follow-up,the two groups displayed decreased clinical symptom scores,inflammatory indices,CD8+,Th17,Th17/Treg,SNOT-20 score,Lung Meridian Heat Accumulation Syndrome score,Lund-Kennedy score,T&T olfactory score(P＜0.05),increased CD4+,Treg,CD4+/CD8+,MTR(P＜0.05),and shortened MTT(P＜0.05),especially for the observation group(P＜0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with refractory rhinosinusitis,the comprehensive treatment regimen of traditional Chinese medicine can safely and effectively improve inflammatory responses,immune functions and mucociliary motor functions,repair the status and functions of nasal mucosa,alleviate subjective and objective symptoms,and enhance life quality.
