Secondary metabolites from endophytic fungi Candida sp.of Berberis atrocarpa
10.3969/j.issn.1001-1528.2024.09.025
- VernacularTitle:黑果小檗内生真菌假丝酵母菌次生代谢产物研究
- Author:
Ming-Zhuo GUO
1
,
2
;
Shu-Fang MA
;
Shi-Miao WANG
;
Ya-Ping FENG
;
Yan OUYANG
;
Ke-Jian PANG
;
Zi-Wei JIAO
;
Xin-Zhou YANG
Author Information
1. 伊犁师范大学,新疆 伊宁 835000
2. 中南民族大学药学院,湖北 武汉 430074
- Keywords:
Berberis atrocarpa Schneid.;
Candida sp.;
endophytic fungi;
secondary metabolites;
isolation and identification
- From:
Chinese Traditional Patent Medicine
2024;46(9):3000-3005
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the secondary metabolites from the endophytic fungi Candida sp.of Berberis atrocarpa Schneid.METHODS The ethyl acetate fraction and petroleum ether fraction from the secondary metabolites of Candida sp.fermentation extract were separated and purified by silica gel,Sephadex LH-20 and preparative liquid chromatography,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eighteen compounds were isolated and identified as 1-phenyl-1,2-ethanediol(1),4-hydroxyphenethyl alcohol(2),4-hydroxybenzoic acid(3),4-hydroxyphenylacetic acid(4),3-hydroxyphenylacetic acid(5),3-methylsulfinyl propionic acid(6),phenylacetic acid(7),(S)-N-nitroso-1-amino-p-hydroxy phenylethanol(8),2-phenylacetamide(9),p-hydroxybenzaldehyde(10),ethyl 2-(4-hydroxyphenyl)acetate(11),dibutyl phthalate(12),5,5'-dimethoxybiphenyl-2,2'-diol(13),3-indolealdehyde(14),N-acetyl-L-phenylalanine(15),9-hydroxy-10E,12Z-octadecadienoic acid(16),9-hydroxy-10E,12E-octadecadienoic acid(17),(6E)-5-methylene-6-tetradecenoic acid(18).CONCLUSION Compounds 1,3-8 and 10-18 are isolated from Candida sp for the first time.
