Chemical constituents from the stems of Gnetum parvifolium and their xanthine oxidase inhibitory activities
10.3969/j.issn.1001-1528.2024.09.024
- VernacularTitle:小叶买麻藤茎化学成分及其黄嘌呤氧化酶抑制活性研究
- Author:
Qian CHEN
1
;
Zheng-Kuan ZHANG
;
Tian-Tian LUO
;
Ai-Fen ZENG
;
Guo-Bo XU
;
Qin-Feng ZHU
;
Shang-Gao LIAO
Author Information
1. 贵州医科大学药学院/省部共建药用植物功效与利用国家重点实验室,贵州 贵阳 550025
- Keywords:
Gnetum parvifolium(Warb.)C.Y.Cheng ex Chun;
stems;
chemical constituents;
isolation and identification;
xanthine oxidase
- From:
Chinese Traditional Patent Medicine
2024;46(9):2994-2999
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the stems of Gnetum parvifolium(Warb.)C.Y.Cheng ex Chun and their xanthine oxidase inhibitory activities.METHODS The 95%ethanol extract from the stems of G.parvifolium was isolated and purified by silica gel,MCI and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The inhibitory activities on xanthine oxidase was determined by ultraviolet spectrophotometry.RESULTS Seventeen compounds were isolated and identified as isorhapontigenin(1),resveratrol(2),4-hydroxybenzaldehyde(3),cycloeucalenol(4),(E)-1-(3',5'-dimethoxyphenyl)-2-(3,4-dimethoxyphenyl)ethene(5),stigmast-4-en-3-one(6),medioresinol(7),chrysin(8),aurantiamide acetate(9),(-)-pinoresinol(10),methyl 4-hydroxybenzoate(11),2-methoxybenzene-1,4-diol(12),gnetumontain C(13),syringaresinol(14),homoeriodictyol(15),vanillin(16),β-sitosterol(17).The IC50 values of compounds 1-3,15-16 were(11.4±0.54),(14.1±1.06),(320.4±0.75),(360.6±0.78),(386.3±0.71)μmol/L,respectively.CONCLUSION Compounds 3-4 are isolated from this plant for the first time.Compounds 5-13 are first isolated from genus Gnetum.Compounds 1-3,15-16 have xanthine oxidase inhibitory activities.
